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  • Contrave is looking very promising for anyone seeking a diet pill that work well. The U.S. Food and Drug Administration reviewed Contrave on December 7, and approved the drug 13-7, stating the benefit of the drug outweighs the potential risk of a possible surge in blood pressure.

    Using two separate drugs to lose weight can be very effective you will find combinations while watching FDA now awaiting approval. When dealing with weight reduction and the those who go through it one should err along the side of caution and permit the FDA do its job and demand some study be done so that the public recognizes the side effects and risks of the medications before we bring them. Keep in mind that drug companies have been in business to generate money and that they would say anything to keep people on the medications.

    Researchers found out that participants taking this drug for the year, dropped a few pounds within 4 weeks and have kept the load off during the entire 56 weeks of the study. Contrave is really a combination of the drugs naltrexone and bupropion, which seems to reflect a brand new trend of weight-loss drugs which might be made up of more than one active ingredient, which can make them more effective and safer.

    Combo-pilling may be the newest fad or better yet the newest to come under scrutiny and so it is just more publicly known recently, comb-pilling for weight reduction has been around since the eighties. The biggest reason that using a combination of pills is starting to become popular could be the fact that since right now there are not any long term prescription weightloss pills that have been licensed by the FDA aside from orlistat. The truly disturbing part is doctors are prescribing these combinations of medications however some of the combinations are already rejected or have yet to be authorized by the FDA.

    Seizures are a side effect with Contrave and really should not be taken in people with seizure disorders. The drug could also raise blood pressure and pulse rate, and must not be used in individuals with a history of heart attack or stroke in the last six months. Blood pressure and pulse should also be measured before beginning the drug and throughout therapy using the drug.

    The FDA also warned that Contrave can raise blood pressure and heart rate and must not be used in patients with uncontrolled high blood pressure level, along with by a person with heart-related and cerebrovascular (circulatory dysfunction impacting your brain) disease. Patients which has a history of cardiac event or stroke in the last six months, life-threatening arrhythmias, or congestive heart failure were excluded through the clinical trials. Those taking Contrave needs to have their heart-rate and pulse monitored regularly. In addition, since the compound includes bupropion, Contrave comes using a boxed warning to alert health care professionals and patients to the increased chance of suicidal thoughts and behaviors associated with antidepressant drugs. The warning also notes that serious neuropsychiatric events are already reported in patients taking bupropion for stopping smoking.

    Suboxone contains two drugs; buprenorphine and naloxone. The naloxone is irrelevant when the addict uses the medication properly, but if the tablet is dissolved in water and injected the naloxone can cause instant withdrawal. When suboxone is used correctly, the naloxone is destroyed inside the liver soon after uptake from the intestines and it has no therapeutic effect. Buprenorphine may be the active substance; it can be absorbed under the tongue (and through the mouth) but destroyed with the liver if swallowed. There is a formulation of buprenorphine without naloxone called subutex; I purchased this formulation in the event the patient has apparent problems from naloxone, including headaches after dosing with suboxone. I have treated addicts who've had gastric bypass, the location where the first part of the intestine is bypassed as well as the stomach contents empty in to a more distal the main small intestine. In such cases the naloxone escapes ?first pass metabolism', the method with normal anatomy the location where the drug is taken up by the duodenum and transferred directly to the liver with the portal vein, where it really is quickly and completely destroyed. After gastric bypass naloxone can be taken up by portions of the intestine that aren't served with the portal system, causing blood degrees of naloxone sufficient to cause brief, relatively mild withdrawal symptoms.